國家衛生研究院 NHRI:Item 3990099045/12610
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    题名: Visualization of endogenous type I TGF-beta receptor baboon in the drosophila brain
    其它题名: Visualization of endogenous type I TGF-β receptor baboon in the drosophila brain
    作者: Lai, YW;Chu, SY;Li, JC;Chen, PL;Chen, CH;Yu, HH
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: The transforming growth factor beta (TGF-beta) signaling pathway is evolutionarily conserved and widely used in the animal kingdom to regulate diverse developmental processes. Prior studies have shown that Baboon (Babo), a Drosophila type I TGF-beta receptor, plays essential roles in brain development and neural circuit formation. However, the expression pattern for Babo in the developing brain has not been previously reported. We generated a knock-in fly with a human influenza hemagglutinin (HA) tag at the C-terminus of Babo and assessed its localization. Babo::HA was primarily expressed in brain structures enriched with neurites, including the mushroom body lobe and neuropils of the optic lobe, where Babo has been shown to instruct neuronal morphogenesis. Since the babo 3' untranslated region contains a predicted microRNA-34 (miR-34) target sequence, we further tested whether Babo::HA expression was affected by modulating the level of miR-34. We found that Babo was upregulated by mir-34 deletion and downregulated by miR-34 overexpression, confirming that it is indeed a miR-34 target gene. Taken together, our results demonstrate that the babo(HA) fly permits accurate visualization of endogenous Babo expression during brain development and the construction of functional neural circuits.
    日期: 2020-03-20
    關聯: Scientific Reports. 2020 Mar 20;10:Article number 5132.
    Link to: http://dx.doi.org/10.1038/s41598-020-61950-y
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000563415000009
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85082092530
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