國家衛生研究院 NHRI:Item 3990099045/12631
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    题名: A novel deletion mutation in pmrB contributes to concurrent colistin resistance in carbapenem-resistant escherichia coli sequence type 405 of clinical origin
    作者: Wang, CH;Siu, LK;Chang, FY;Tsai, YK;Lin, YT;Chiu, SK;Huang, LY;Lin, JC
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: We report the first clinical Escherichia. coli strain EC3000 with concomitant chromosomal colistin and carbapenem resistance. A novel in-frame deletion, Delta6-11(RPISLR), in pmrB contributing to colistin resistance was verified using recombinant DNA techniques. Although decreased fitness compared to the wild-type (WT) strain or EC3000 revertant (chromosomal replacement of WT pmrB in EC3000), a portion of serially passaged EC3000 strains preserving colistin resistance without selective pressure raises the concern for further spread.
    日期: 2020-06
    關聯: Antimicrobial Agents and Chemotherapy. 2020 Jun;64(6):e00220-20.
    Link to: http://dx.doi.org/10.1128/aac.00220-20
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000535946300016
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085265818
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