國家衛生研究院 NHRI:Item 3990099045/1263
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1263


    题名: Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors
    作者: Romagnoli, R;Baraldi, PG;Sarkar, T;Carrion, MD;Cara, CL;Cruz-Lopez, O;Preti, D;Tabrizi, MA;Tolomeo, M;Grimaudo, S;Di Cristina, A;Zonta, N;Balzarini, J;Brancale, A;Hsieh, HP;Hamel, E
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: The 2-(3,4,5-trimethoxybenzoyl)-2-aminoindole nucleus was used as the fundamental structure for the synthesis of compounds modified with respect to positions C-4 to C-7 with different moieties (chloro, methyl, or methoxy). Additional structural variations concerned the indole nitrogen, which was alkylated with small alkyl groups such as methyl or ethyl. We have identified 1-methyl-2-(3,4,5-trimethoxybenzoyl)-3-amino-7-methoxyindole as a new highly potent anti proliferative agent that targets tubulin at the colchicine binding site and leads to apoptotic cell death.
    关键词: Chemistry, Medicinal
    日期: 2008-03-13
    關聯: Journal of Medicinal Chemistry. 2008 Mar;51(5):1464-1468.
    Link to: http://dx.doi.org/10.1021/jm7011547
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000253784900040
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41649113513
    显示于类别:[謝興邦] 期刊論文

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