國家衛生研究院 NHRI:Item 3990099045/12661
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    题名: Plasmid- and chromosome-located mcr-3 in mcr-1-positive Escherichia coli in Taiwan
    作者: Hsu, CY;Chen, FJ;Huang, WC;Liao, YC;Lauderdale, TL;Kuo, SC
    贡献者: National Institute of Infectious Diseases and Vaccinology;Institute of Population Health Sciences
    摘要: The mobile colistin resistance gene, mcr-1, and its variants have been detected among humans and domestic animals worldwide. Since its first detection in 2017, mcr-3 has been reported in Asia, Europe and North America. Here, we describe the presence of mcr-3 in diverse plasmids and the chromosome in Escherichia coli from diseased swine, and the co-occurrence of plasmid-located mcr-1. E. coli isolates from humans, retail meat, and diseased swine (n= 7942, 537, and 645, respectively) were subjected to reference broth microdilution method. A part of human and meat isolates have been published for the prevalence of mcr-1 [1] (please see Supplementary methods for the details). PCR targeting mcr-1 to mcr-8 was performed on colistin-resistant isolates. Only mcr-1 was detected in 58 and 41 isolates from humans and meat, respectively. Among isolates from diseased swine, 330 were positive for mcr-1 only, seven were positive for mcr-3 only and three were concomitantly positive for mcr-1 and mcr-3. The 10 mcr-3-positive isolates were multi-drug resistant but the co-occurrence of mcr-1 and mcr-3 did not increase colistin MICs (Supplementary Table S1).
    日期: 2020-07
    關聯: International Journal of Antimicrobial Agents. 2020 Jul;56(1):Article number 105996.
    Link to: http://dx.doi.org/10.1016/j.ijantimicag.2020.105996
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000552613500040
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085350977
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