For metastatic prostate cancer (PCa), the current standard treatment is androgen deprivation therapy (ADT). However, therapy-resistant tumors, named metastatic castration-resistant prostate cancer (mCRPC), recur in most ADT-treating patients within 3 years and the overall survival time is usually less than 2 years after the relapse (1,2). Docetaxel and two inhibitors targeting androgen receptor (AR) pathway, the abiraterone acetate and enzalutamide, are used for treatment of CRPC. The treatments increased survival as well as reduced pain and serum PSA level (3-6). However, a portion of CRPC patients receiving these drugs develop drug-resistance within a few months (7,8). New therapeutic strategies targeting the treatment-refractory mCRPC are therefore in need. Classification of cancers into subtypes with distinct histological and functional features may assist the development of new targeted therapies.
Date:
2020-04
Relation:
Translational Andrology and Urology. 2020 Apr;9(2):837-839.
