國家衛生研究院 NHRI:Item 3990099045/12677
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    题名: Post-translational modifications of transcription factors harnessing the etiology and pathophysiology in colonic diseases
    作者: Hsu, CY;Fu, SH;Chien, MW;Liu, YW;Chen, SJ;Sytwu, HK
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Defects in mucosal immune balance can lead to colonic diseases such as inflammatory bowel diseases and colorectal cancer. With the advancement of understanding for the immunological and molecular basis of colonic disease, therapies targeting transcription factors have become a potential approach for the treatment of colonic disease. To date, the biomedical significance of unique post-translational modifications on transcription factors has been identified, including phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O- GlcNAcylation. This review focuses on our current understanding and the emerging evidence of how post-translational regulations modify transcription factors involved in the etiology and pathophysiology of colonic disease as well as the implications of these findings for new therapeutic approaches in these disorders.
    日期: 2020-05-01
    關聯: International Journal of Molecular Sciences. 2020 May 1;21(9):Article number 3207.
    Link to: http://dx.doi.org/10.3390/ijms21093207
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000535581700178
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85084229844
    显示于类别:[司徒惠康] 期刊論文

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