國家衛生研究院 NHRI:Item 3990099045/12706

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12706

Title:	Three-dimensional printed porous titanium screw with bioactive surface modification for bone-tendon healing: A rabbit animal model
Authors:	Huang, YM;Huang, CC;Tsai, PI;Yang, KY;Huang, SI;Shen, HH;Lai, HJ;Huang, SW;Chen, SY;Lin, FH;Chen, CY
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	The interference screw fixation method is used to secure a graft in the tibial tunnel during anterior cruciate ligament reconstruction surgery. However, several complications have been reported, such as biodegradable screw breakage, inflammatory or foreign body reaction, tunnel enlargement, and delayed graft healing. Using additive manufacturing (AM) technology, we developed a titanium alloy (Ti(6)Al(4)V) interference screw with chemically calcium phosphate surface modification technology to improve bone integration in the tibial tunnel. After chemical and heat treatment, the titanium screw formed a dense apatite layer on the metal surface in simulated body fluid. Twenty-seven New Zealand white rabbits were randomly divided into control and additive manufactured (AMD) screw groups. The long digital extensor tendon was detached and translated into a tibial plateau tunnel (diameter: 2.0 mm) and transfixed with an interference screw while the paw was in dorsiflexion. Biomechanical analyses, histological analyses, and an imaging study were performed at 1, 3, and 6 months. The biomechanical test showed that the ultimate pull-out load failure was significantly higher in the AMD screw group in all tested periods. Micro-computed tomography analyses revealed early woven bone formation in the AMD screw group at 1 and 3 months. In conclusion, AMD screws with bioactive surface modification improved bone ingrowth and enhanced biomechanical performance in a rabbit model.
Date:	2020-05-21
Relation:	International Journal of Molecular Sciences. 2020 May 21;21(10):Article number 3628.
Link to:	http://dx.doi.org/10.3390/ijms21103628
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000539312100224
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085372010
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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