國家衛生研究院 NHRI:Item 3990099045/12715
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    题名: Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
    作者: Chen, PL;Huang, KT;Cheng, CY;Li, JC;Chan, HY;Lin, TY;Su, MP;Yang, WY;Chang, HC;Wang, HD;Chen, CH
    贡献者: National Institute of Infectious Diseases and Vaccinology;Institute of Molecular and Genomic Medicine;National Mosquito-Borne Diseases Control Research Center
    摘要: Mitochondrial aging, which results in mitochondrial dysfunction, is strongly linked to many age-related diseases. Aging is associated with mitochondrial enlargement and transport of cytosolic proteins into mitochondria. The underlying homeostatic mechanisms that regulate mitochondrial morphology and function, and their breakdown during aging, remain unclear. Here, we identify a mitochondrial protein trafficking pathway in Drosophila melanogaster involving the mitochondria-associated protein Dosmit. Dosmit induces mitochondrial enlargement and the formation of double-membraned vesicles containing cytosolic protein within mitochondria. The rate of vesicle formation increases with age. Vesicles originate from the outer mitochondrial membrane as observed by tracking Tom20 localization, and the process is mediated by the mitochondria-associated Rab32 protein. Dosmit expression level is closely linked to the rate of ubiquitinated protein aggregation, which are themselves associated with age-related diseases. The mitochondrial protein trafficking route mediated by Dosmit offers a promising target for future age-related mitochondrial disease therapies.
    日期: 2020-05-22
    關聯: Nature Communications. 2020 May 22;11:Article number 2592.
    Link to: http://dx.doi.org/10.1038/s41467-020-16335-0
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000537135100013
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085264569
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