國家衛生研究院 NHRI:Item 3990099045/12795
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12795


    Title: Method for generating immunomodulatory cells, the cells prepared therefrom, and use thereof
    Authors: Yen, LJ;Liu, KJ;Sytwu, HK
    Contributors: Institute of Cellular and Systems Medicine;National Institute of Cancer Research
    Abstract: The present invention develops a straightforward and rapid method for generating immunomodulatory cells from peripheral mononuclear cells, comprising treating peripheral mononuclear cells with a hepatocyte growth factor (HGF) to induce differentiation of the peripheral mononuclear cells into immunomodulatory leukocytes. The present invention also provides an immunomodulatory cell prepared according to this method. The present invention further provides a method for treating a disease caused by abnormal immune response comprising administering a HGF to a patient exhibiting the disease, inducing the patient's peripheral mononuclear cells to differentiate into immunomodulatory leukocytes, and modulating the abnormal immune response. | | La présente invention concerne une méthode rapide et directe permettant de générer des cellules immunomodulatrices à partir de cellules mononucléaires périphériques, consistant à traiter des cellules mononucléaires périphériques avec un facteur de croissance de cellules hépatiques (HGF) afin d'induire la différenciation des cellules mononucléaires périphériques en leucocytes immunomodulateurs. La présente invention concerne également une cellule immunomodulatrice préparée selon cette méthode. La présente invention concerne en outre une méthode de traitement d'une maladie provoquée par une réponse immunitaire anormale consistant à administrer un HGF à un patient atteint de cette maladie, induire la différenciation des cellules mononucléaires périphériques du patient en leucocytes immunomodulateurs, et moduler la réponse immunitaire anormale.
    Date: 2018-06-13
    Relation: EP2893005/2018-06-13
    Link to: https://www.derwentinnovation.com/tip-innovation/recordView.do?datasource=T3&category=PAT&selRecord=1&totalRecords=1&databaseIds=PATENT&recordKeys=EP2893005A1
    Appears in Collections:[Betty Lin-Ju Yen] Patents
    [Ko-Jiunn Liu] Patents

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