國家衛生研究院 NHRI:Item 3990099045/12828
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    题名: Sialidase activity in human blood serum has a distinct seasonal pattern: A pilot study
    作者: Glanz, VY;Kashirskikh, DA;Grechko, AV;Yet, SF;Sobenin, IA;Orekhov, AN
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Desialylation—loss of terminal sialic acid residues from glycoconjugates catalyzed by sialidases—is involved in many human diseases and is considered a key molecular event of atherosclerosis onset. Desialylated low‐density lipoproteins with atherogenic properties have been detected in human blood previously. However, there is currently no consensus on the origin of desialylation activity in the bloodstream. Here, we suggest viral intervention as a possible explanation. In order to address our hypothesis, we studied seasonal patterns of blood serum sialidase enzymatic activity and designed an approach to detect and quantify viral sialidase genetic presence. Increased sialidase activity in autumn‐winter combined with detectable levels of influenza virus sialidase mRNA suggests exogenous viral sialidase as a viable component of desialylation in human blood, providing new insights on the molecular background of atherogenesis.
    日期: 2020-07-22
    關聯: Biology. 2020 Jul 22;9(8):Article number 184.
    Link to: http://dx.doi.org/10.3390/biology9080184
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2079-7737&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000564063800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85088291096
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