國家衛生研究院 NHRI:Item 3990099045/12830

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Title:	Serum neurofilament light polypeptide is a biomarker for inflammation in cerebrospinal fluid caused by fine particulate matter
Authors:	Hsiao, TC;Chang, JS;Wang, JY;Wu, DA;Chuang, KJ;Chen, JK;Cheng, TJ;Chuang, HC
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Epidemiological and toxicological evidence indicates that fine particulate matter (PM2.5, particulate matter < 2.5 mu m in aerodynamic diameter) causes cardiopulmonary toxicity; however, its neurotoxic effects remain unclear. The objective of this study was to investigate the role of the neurofilament light (NEFL) serum polypeptide in neurotoxicity. 6-month-old male Sprague Dawley (SD) rats were exposed to traffic-related PM1 (< 1 mu m in aerodynamic diameter; 16.3 mu g m(-3)) and gaseous pollutants (via high-efficiency particulate air, HEPA) for 3 and 6 months through a whole-body exposure system. According to our observations, the levels of interleukin (IL)-4, IL-10, and tumor necrosis factor (TNF)-alpha in the serum of the rats significantly increased (p < 0.05) after 3 months of exposure to PM1, whereas that of NEFL polypeptide significantly increased (p < 0.05) after 3 and 6 months of exposure. Additionally, increases in the IL-2, IL-6, IL-10, IL-17a, TNF-alpha, and interferon (IFN)-gamma levels after 3 and/or 6 months of exposure to this pollutant (p < 0.05) were observed in the cerebrospinal fluid (CSF). In terms of their respective levels, the IL-6 correlated well with the CSF IL-2 and IL-10; the TNF-alpha correlated well with the CSF IL-6, IL-17a, TNF-alpha, and IFN-gamma; and the NEFL polypeptide correlated well with the CSF IL-2, IL-4, IL-6, IL-10, IL-17a, TNF-alpha, and IFN-gamma. In summary, systemic neuroinflammatory and immune responses in rats occurred after chronic exposure to PM1. Hence, NEFL polypeptide in serum may be a suitable biomarker for neurotoxicity caused by chronic exposure to this pollutant.
Date:	2020-07
Relation:	Aerosol and Air Quality Research. 2020 Jul;20(7):1665-1669.
Link to:	http://dx.doi.org/10.4209/aaqr.2019.08.0376
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1680-8584&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000548340000014
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85087336643
Appears in Collections:	[Jen-Kun Chen] Periodical Articles

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