國家衛生研究院 NHRI:Item 3990099045/12894
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    題名: The factors associated with insulin nonpersistence in persons with type 2 diabetes
    作者: Yen, FS;Wei, JCC;Liu, JS;Hsu, CC;Hwu, CM
    貢獻者: Institute of Population Health Sciences
    摘要: Aims: Implementation of insulin therapy among those with diabetes is often suboptimal as a result of non-adherence or non-persistence. Studies regarding factors leading to insulin nonpersistence are limited. Therefore, we conducted this retrospective cohort study to determine the factors affecting insulin nonpersistence. Methods: A total of 274,852 persons with type 2 diabetes mellitus under insulin therapy during the period 2000–2014 were enrolled. Persons who stopped insulin therapy for >90 days were defined as having insulin nonpersistence. We searched for factors associated with insulin nonpersistence during the long-term follow-up period. Results: According to the multiple Cox regression model with a mean follow-up of 13.9 years, the factors associated with higher risk of insulin nonpersistence were age <40 years, men, residing in a rural area, Charlson comorbidity index score = 4, use of two or more oral antidiabetic drugs, and hypoglycemia during follow-up. The Kaplan–Meier graph showed that patients aged <40 years had significantly less insulin persistence. Conclusions: This nationwide cohort study indicated that persons with young-onset type 2 diabetes, less medical resources, and more comorbidities are at risk of insulin nonpersistence. Healthcare providers should regularly assess insulin persistence and help patients who are having difficulty with insulin-taking.
    日期: 2020-09
    關聯: Diabetes Research and Clinical Practice. 2020 Sep;167:Article number 108356.
    Link to: http://dx.doi.org/10.1016/j.diabres.2020.108356
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0168-8227&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000580069500018
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85089224372
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