國家衛生研究院 NHRI:Item 3990099045/12895

NHRI > Institute of Population Health Sciences > Ching-Yu Chen(2006-2010) > Periodical Articles > Item 3990099045/12895

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12895

Title:	Plasma vascular adhesion protein-1 levels correlate positively with frailty severity in older adults
Authors:	Huang, HL;Chang, CH;Chen, CY;Peng, JK;Wang, YT;Chen, CY;Hsu, CC;Lee, CS;Tsai, JS
Contributors:	Institute of Population Health Sciences
Abstract:	Geriatric frailty is associated with increased mortality and links to increased inflammatory activity. Vascular adhesion protein-1 (VAP-1) is important in inflammatory process. This study investigates the relationship between plasma VAP-1 level and frailty in older adults. The cross-sectional study recruited community dwelling older adults from a hospital-based comprehensive geriatric assessment program. The demographic data, Fried Frailty Index, metabolic and inflammatory parameters were assessed. A total of 151 participants (76 women, 50.3%) were included in the analysis, and the age (mean +/- standard deviation) was 77.1 +/- 6.1 years. The mean plasma VAP-1 level (ng/mL) was significantly different (P = .029) among different frailty groups (346.3 +/- 86.5 in the robust older adults, 371.6 +/- 107.9 in the pre-frail older adults, and 416.6 +/- 141.1 in the frail older adults). Multivariate ordered logistic regression analysis also demonstrated that plasma VAP-1 levels were positively associated with frailty severity (P = .039). Analysis of the frailty components with plasma VAP-1 levels showed that the elderly who had "exhaustion" (P = .016) or "weakness" (P = .025) tended to have higher plasma VAP-1 levels. The data support that VAP-1 might represent a potential plasma biomarker of frailty.
Date:	2020-07-24
Relation:	Medicine. 2020 Jul 24;99(30):Article number e21192.
Link to:	http://dx.doi.org/10.1097/md.0000000000021192
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0025-7974&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000558420900041
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85089525359
Appears in Collections:	[Ching-Yu Chen(2006-2010)] Periodical Articles [Chih-Cheng Hsu] Periodical Articles

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