國家衛生研究院 NHRI:Item 3990099045/12915
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    题名: Radiation dose escalation can improve local disease control and survival among esophageal cancer patients with large primary tumor volume receiving definitive chemoradiotherapy
    作者: Lin, FC;Chang, WL;Chiang, NJ;Lin, MY;Chung, TJ;Pao, TH;Lai, WW;Tseng, YL;Yen, YT;Sheu, BS
    贡献者: National Institute of Cancer Research
    摘要: Background This study aimed to investigate the correlation between primary tumor volume and cancer failure patterns in esophageal squamous cell carcinoma (ESCC) treated with definitive concurrent chemoradiotherapy (CCRT) and examine whether increasing radiation dose can improve the outcome. Methods We retrospectively reviewed 124 patients with stage III ESCC treated by definitive CCRT. The primary tumor volume calculated from the radiotherapy planning computed tomography scans was correlated to treatment response, time to disease progression, and overall survival. We further analyzed whether a higher radiation dose correlated with better disease control and patient survival. Results Patients with poor CCRT response had a larger primary tumor volume than those with good response (97.9vs64.3 cm(3),P= 0.032). The optimal cutoff value to predict CCRT response was 55.3 cm(3). Large primary tumor volume (>= 55.3 cm(3)) correlated with shorter time to tumor progression in the esophagus (13.6vs48.6 months,P= 0.033) compared with small tumor volume (< 55.3 cm(3)). For the large esophageal tumors (>= 55.3 cm(3)), radiation dose > 60 gray significantly prolonged the time to tumor progression in esophagus (20.3vs10.1 months,P= 0.036) and overall survival (12.2vs8.0 months,P= 0.030), compared with dose <= 60 gray. In contrast, higher radiation dose did not benefit local disease control or overall survival in the small esophageal tumors (< 55.3 cm(3)). Conclusion Large primary tumor volume correlates with poor local control and overall survival in ESCC treated with definitive CCRT. Radiation dose > 60 gray can improve the outcomes in patients with large primary tumor. Further prospective dose escalation trials are warranted.
    日期: 2020-08
    關聯: PLoS ONE. 2020 Aug;15(8):Article number e0237114.
    Link to: http://dx.doi.org/10.1371/journal.pone.0237114
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000561027200039
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85089170795
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