English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12441/13613 (91%)
造訪人次 : 2356577      線上人數 : 80
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    主頁登入上傳說明關於NHRI管理 到手機版
    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12927


    題名: Metabolomic differences of exhaled breath condensate among children with and without asthma
    作者: Chang-Chien, J;Huang, HY;Tsai, HJ;Lo, CJ;Lin, WC;Tseng, YL;Wang, SL;Ho, HY;Cheng, ML;Yao, TC
    貢獻者: Institute of Population Health Sciences
    摘要: BACKGROUND: There remains an unmet need in objective tests for diagnosing asthma in children. The objective of this study was to investigate the potential of metabolomic profiles of exhaled breath condensate (EBC) to discriminate stable asthma in Asian children in the community. METHODS: One hundred sixty-fiveAsian children (92 stable asthma and 73 non-asthmatic controls) participating in a population-based cohort were enrolled and divided into training and validation sets. Nuclear magnetic resonance-based metabolomic profiles of EBC samples were analyzed by using orthogonal partial least squares discriminant analysis. RESULTS: EBC metabolomic signature (lactate, formate, butyrate and isobutyrate) had an area under the Receiver Operator Characteristic curve (AUC) of 0.826 in discriminating children with and without asthma in the training set, which significantly outperformed FeNO (AUC = 0.574; P<0.001) and FEV(1) /FVC % predicted (AUC = 0.569; P<0.001). The AUC for EBC metabolomic signature was 0.745 in the validation set, which was slightly but not significantly lower than in the testing set (P = 0.282).We further extrapolated two potentially involved metabolic pathways, including pyruvate (P=1.67×10(-3) ; impact: 0.14) and methane (P=1.89×10(-3) ; impact: 0.15), as the most likely divergent metabolisms between children with and without asthma. CONCLUSION: This study provided evidence supporting the role of EBC metabolomicsignature to discriminate stable asthma in Asian children in the community, with a discriminative property outperforming conventional clinical tests such asFeNOor spirometry.
    日期: 2021-02
    關聯: Pediatric Allergy and Immunology. 2021 Feb;32(2):264-272.
    Link to: http://dx.doi.org/10.1111/pai.13368
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0905-6157&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000573704100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85091725804
    顯示於類別:[蔡慧如] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB32920883.pdf4961KbAdobe PDF260檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋