國家衛生研究院 NHRI:Item 3990099045/12970
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12970


    Title: Human placental MSC-secreted IL-1Beta enhances neutrophil bactericidal functions during hypervirulent klebsiella infection
    Other Titles: Human placental MSC-secreted IL-1β enhances neutrophil bactericidal functions during hypervirulent klebsiella infection
    Authors: Wang, LT;Wang, HH;Chiang, HC;Huang, LY;Chiu, SK;Siu, LK;Liu, KJ;Yen, ML;Yen, BL
    Contributors: Institute of Cellular and Systems Medicine;National Institute of Infectious Diseases and Vaccinology;National Institute of Cancer Research
    Abstract: Hypervirulent Klebsiella pneumoniae (hvKP) causes severe infections even in healthy individuals by escaping surveillance and killing from polymorphonuclear neutrophils (PMNs), the first-line leukocytes in bacterial infections; moreover, the emergence of multidrug-resistant strains further limits treatment options. We therefore assess whether multilineage mesenchymal stem cells (MSCs), best known for immunomodulation toward T cells, could be therapeutic for highly virulent bacterial infections via modulation of PMNs. We find that both bone marrow MSCs and placental MSCs (PMSCs) preserve in vitro PMN survival, but only PMSCs significantly enhance multiple PMN bactericidal functions, including phagocytosis, through secretion of interleukin-1β (IL-1β). PMSC treatment of hvKP-infected mice suppresses T and natural killer (NK) cell responses as expected but can preferentially recruit PMNs and enhance antibacterial functions to allow for disease survival; IL-1β knockdown in PMSCs significantly decreases hvKP clearance, worsening survival and resulting in 100% lethality. Our data strongly implicate the possible use of PMSCs for infections of PMN-resistant hvKP strains.
    Date: 2020-09-29
    Relation: Cell Reports. 2020 Sep 29;32(13):Article number 108188.
    Link to: http://dx.doi.org/10.1016/j.celrep.2020.108188
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2211-1247&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000573722100003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85091698603
    Appears in Collections:[Betty Lin-Ju Yen] Periodical Articles
    [Leung-Kei Siu] Periodical Articles
    [Ko-Jiunn Liu] Periodical Articles

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