We read with interest the letter to the editor by Hermasch et al. in this journal (Hermasch et al., 2020). The authors comment on our recent findings on a zebrafish insertional nicastrin mutant (Hsu et al., 2020). We showed that zebrafish nicastrin deficiency leads to melanosome defects, Tyrosinase-dependent mitochondrial swelling, and melanophore cell death. Based on several clinical observations and animal model studies, we proposed that this animal model may be used for investigating depigmentaion-related skin diseases and for screening potential drugs (Hsu et al., 2020). Nevertheless, Hermasch et al. raise some questions and concerns, to which we reply hereafter.
Date:
2021-05
Relation:
Journal of Investigative Dermatology. 2021 May;141(5):1334-1338.
