國家衛生研究院 NHRI:Item 3990099045/12992
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    题名: Effect of a neuropilin-1-derived virus receptor trap on enterovirus A71 infection in vitro
    作者: Wang, HC;Huang, PN;Hung, HC;Tseng, SN;Chang, CC;Tsai, YR;Wang, YM;Shih, SR;Hsu, JT
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate Enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not EV-D68 and CVB3. NRP1 recognizes EVA71 through a novel domain on VP3 capsid protein. The principle in the design, engineering and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.
    日期: 2021-01
    關聯: Antimicrobial Agents and Chemotherapy. 2021 Jan;65(1):Article number e00695-20.
    Link to: http://dx.doi.org/10.1128/aac.00695-20
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000600658500008
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85098637216
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