國家衛生研究院 NHRI:Item 3990099045/13020
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    題名: The relationship between resting heart rate and new-onset microalbuminuria in people with type 2 diabetes: An eight-year follow-up study
    作者: Chang, YK;Fan, HC;Lim, PS;Chuang, SY;Hsu, CC
    貢獻者: Institute of Population Health Sciences
    摘要: AIMS: Microalbuminuria is an indicator of adverse cardiovascular events and chronic kidney disease. Studies have described an elevated resting heart rate as a risk factor for microalbuminuria in people with cardiovascular disease, but none have clarified its role in microalbuminuria development in people with type 2 diabetes. Therefore, this study investigated the relationship between resting heart rate and new-onset microalbuminuria in type 2 diabetes. METHODS: A total of 788 people from a glycemic control trial in Taiwan were enrolled. Microalbuminuria was defined as a fasting urine albumin-to-creatinine ratio ≥30 mg/g in two consecutive urine tests. The resting heart rate and other covariates were measured at baseline. The quartile of resting heart rates, categorized as <70, 70-74, 75-80, and >80 beats/min, was used for analysis. Cox proportional hazard models were used to evaluate the association between resting heart rate and risk of microalbuminuria. RESULTS: During the follow-up period, 244 people (31%) developed microalbuminuria. Those who developed microalbuminuria had a longer diabetes duration (median=3.0 vs. 2.0 years, p<0.001), higher rate of hypertension (77% vs. 66%, p=0.003), higher rate of ACE inhibitor/angiotensin receptor blocker treatment (50% vs. 38%, p=0.001), and higher baseline HbA1c level (70 vs. 64 mmol/mol, 8.6 vs. 8.0 %, p<0.001). After adjusting for demographics, metabolic profiles, and inflammatory markers, developing microalbuminuria was significantly associated with baseline resting heart rate of 70-74, 75-80, and >80 beats/min (with hazard ratios (95%CI) of 2.05 (1.32, 3.18), 2.10 (1.32, 3.32), and 1.62 (1.01, 2.59), respectively) compared to resting heart rates <70 beats/min. An average increased risk of microalbuminuria for increment of 10 beats/min was about 24% among those with hypertension (with hazard ratios of 1.24 (1.05, 1.47) in the multivariable Cox model). CONCLUSIONS: This prospective cohort study showed that resting heart rate may be an associative risk factor for developing microalbuminuria in type 2 diabetes.
    日期: 2021-05
    關聯: Diabetic Medicine. 2021 May;38(5):Article number e14436.
    Link to: http://dx.doi.org/10.1111/dme.14436
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0742-3071&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000590124400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85096660316
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