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    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/13059


    題名: Formation and characterization of hydrogenated soybean lecithin/TPGS nano-dispersions as a potential carrier for active herbal agents
    作者: Shen, PT;Chiu, SW;Chang, JY;Chung, TW;Liang, CH;Deng, MJ;Chou, TH
    貢獻者: Core Instrument Center
    摘要: The goal of this study was to examine the effects of lipid composition on physicochemical characteristics of hydrogenated soybean lecithin (HL)/d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) dispersions using dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and fluorescence polarization spectroscopy. Our results showed that HL-rich nano-dispersions exhibited larger size, narrower size distribution, higher negative zeta potential, more obvious phase transition regions, and lower membrane fluidity than did the TPGS-rich ones. The membrane packing order, intermolecular attraction interaction, and molecular cooperativity in the phase transition region of the HL dispersions could be reduced by the incorporation of a large amount of TPGS. Furthermore, chemical stability, a drug release profile, and free radical-scavenging capacity of HL/TPGS nano-dispersions encapsulating black soybean seed coat extract (BE) were analyzed. HL/TPGS nano-dispersions improved the stability and radical-scavenging capacity of phytochemicals, such as BE. Nano-dispersions with the molar ratio of HL/TPGS = 9/1 exhibited good storage stability, a slow BE release rate, good free radical-scavenging capacity, and high in vitro biocompatibility; thus, they could be a high-potential vehicle for carrying active herbal agents.
    日期: 2021-02
    關聯: Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021 Feb;611:Article number 125796.
    Link to: http://dx.doi.org/10.1016/j.colsurfa.2020.125796
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0927-7757&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000605576800004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85095773100
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