國家衛生研究院 NHRI:Item 3990099045/13074
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    题名: Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery
    作者: Wu, WK;Panyod, S;Liu, PY;Chen, CC;Kao, HL;Chuang, HL;Chen, YH;Zou, HB;Kuo, HC;Kuo, CH;Liao, BY;Chiu, THT;Chung, CH;Lin, AYC;Lee, YC;Tang, SL;Wang, JT;Wu, YW;Hsu, CC;Sheen, LY;Orekhov, AN;Wu, MS
    贡献者: Institute of Population Health Sciences
    摘要: The capability of gut microbiota in degrading foods and drugs administered orally can result in diversified efficacies and toxicity interpersonally and cause significant impact on human health. Production of atherogenic trimethylamine N-oxide (TMAO) from carnitine is a gut microbiota-directed pathway and varies widely among individuals. Here, we demonstrated a personalized TMAO formation and carnitine bioavailability from carnitine supplements by differentiating individual TMAO productivities with a recently developed oral carnitine challenge test (OCCT). By exploring gut microbiome in subjects characterized by TMAO producer phenotypes, we identified 39 operational taxonomy units that were highly correlated to TMAO productivity, including Emergencia timonensis, which has been recently discovered to convert γ-butyrobetaine to TMA in vitro. A microbiome-based random forest classifier was therefore constructed to predict the TMAO producer phenotype (AUROC = 0.81) which was then validated with an external cohort (AUROC = 0.80). A novel bacterium called Ihubacter massiliensis was also discovered to be a key microbe for TMA/TMAO production by using an OCCT-based humanized gnotobiotic mice model. Simply combining the presence of E. timonensis and I. massiliensis could account for 43% of high TMAO producers with 97% specificity. Collectively, this human gut microbiota phenotype-directed approach offers potential for developing precision medicine and provides insights into translational research.
    日期: 2020-11-19
    關聯: Microbiome. 2020 Nov 19;8:Article number 162.
    Link to: http://dx.doi.org/10.1186/s40168-020-00912-y
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2049-2618&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000595703900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85096339502
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