國家衛生研究院 NHRI:Item 3990099045/13077
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    題名: Clinical and economic impact of intensive care unit-acquired bloodstream infections in Taiwan: A nationwide population-based retrospective cohort study
    作者: Wang, YC;Shih, SM;Chen, YT;Hsiung, CA;Kuo, SC
    貢獻者: Institute of Population Health Sciences;National Institute of Infectious Diseases and Vaccinology
    摘要: OBJECTIVES: To estimate the clinical and economic impact of intensive care unit-acquired bloodstream infections in Taiwan. DESIGN: Retrospective cohort study. SETTING: Nationwide Taiwanese population in the National Health Insurance Research Database and the Taiwan Nosocomial Infections Surveillance (2007-2015) dataset. PARTICIPANTS: The first episodes of intensive care unit-acquired bloodstream infections in patients ≥20 years of age in the datasets. Propensity score-matching (1:2) of demographic data, comorbidities and disease severity was performed to select a comparison cohort from a pool of intensive care unit patients without intensive care unit-acquired infections from the same datasets. PRIMARY AND SECONDARY OUTCOME MEASURES: The mortality rate, length of hospitalisation and healthcare cost. RESULTS: After matching, the in-hospital mortality of 14 234 patients with intensive care unit-acquired bloodstream infections was 44.23%, compared with 33.48% for 28 468 intensive care unit patients without infections. The 14-day mortality rate was also higher in the bloodstream infections cohort (4323, 30.37% vs 6766 deaths, 23.77%, respectively; p<0.001). Furthermore, the patients with intensive care unit-acquired bloodstream infections had a prolonged length of hospitalisation after their index date (18 days (IQR 7-39) vs 10 days (IQR 4-21), respectively; p<0.001) and a higher healthcare cost (US$16 038 (IQR 9667-25 946) vs US$10 372 (IQR 6289-16 932), respectively; p<0.001). The excessive hospital stay and healthcare cost per case were 12.69 days and US$7669, respectively. Similar results were observed in subgroup analyses of various WHO's priority pathogens and Candida spp. CONCLUSIONS: Intensive care unit-acquired bloodstream infections in critically ill patients were associated with increased mortality, longer hospital stays and higher healthcare costs.
    日期: 2020-11-26
    關聯: BMJ Open. 2020 Nov 26;10(11):Article number e037484.
    Link to: http://dx.doi.org/10.1136/bmjopen-2020-037484
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2044-6055&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000596216900026
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85096949348
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