國家衛生研究院 NHRI:Item 3990099045/13103
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    题名: A supramolecular bait to trigger non-equilibrium co-assembly and clearance of ABeta42
    其它题名: A supramolecular bait to trigger non-equilibrium co-assembly and clearance of Aβ42
    作者: Wu, TH;Lai, RH;Yao, CN;Juang, JL;Lin, SY
    贡献者: Institute of Biomedical Engineering and Nanomedicine;Institute of Molecular and Genomic Medicine
    摘要: In the living systems, the non-equilibrium states that control the assembly-disassembly of cellular components underlie the gradual complexification of life, whereas in the nonliving systems, most molecules follow the laws of thermodynamic equilibrium to sustain dynamic consistency. However, very little is known about the roles of non-equilibrium states of interactions between supramolecules in living systems. Here, we identified a non-equilibrium state of interaction between supramolecular lipopolysaccharide (LPS) and Aβ42, an aggregate-prone protein that causes Alzheimer's disease (AD). Structurally, the polymerized propagation of Aβ42 presents a specific groove that is recognized by the amphiphilicity of LPS bait in a non-equilibrium manner. Functionally, the transient complex elicits a cellular response to clear extracellular Aβ42 deposits via an endolysosomal mechanism in neuronal cells. Since the impaired clearance of toxic Aβ42 deposits correlates with AD pathology, the non-equilibrium interaction between LPS and Aβ42 could represent a useful target for the development of AD therapeutics.
    日期: 2021-02
    關聯: Angewandte Chemie. 2021 Feb;60(8):4014-4017.
    Link to: http://dx.doi.org/10.1002/anie.202013754
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1433-7851&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000602541200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097604829
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