國家衛生研究院 NHRI:Item 3990099045/13106
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    题名: Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish
    作者: You, MS;Yang, WB;Cheng, CH;Yu, S;Chang, HC;Yu, HS
    贡献者: National Institute of Environmental Health Sciences;Institute of Molecular and Genomic Medicine
    摘要: Although light emitting diodes (LEDs) are widely used in our daily lives, there is little research regarding LED light’'s po.ssible effects on biological functions. We used a zebrafish animal model to investigate the long-term effects of white, blue and red LED lights on cognitive learning and memory recall. Our data suggest that these treatments had not only an impact on learning but also surprisingly long-lasting effects, particularly with regard to individuals treated with red light. The qPCR results revealed that the expression levels of trpm4, trpa1b, grin2aa and dlg4 in the skin were increased after monochromatic light treatment. Furthermore, the up-regulation of trpm4 in the brain may correlate to enhanced learning and memory following red-light treatment. Our results identify a light-based stimulation system for enhancing zebrafish learning, which has the potential to provide important insights into the relationship between LED lighting and animal behaviour.
    日期: 2020-12
    關聯: Journal of Photochemistry and Photobiology B: Biology. 2020 Dec;213:Article number 112073.
    Link to: http://dx.doi.org/10.1016/j.jphotobiol.2020.112073
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1011-1344&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000601341400011
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85096239220
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