國家衛生研究院 NHRI:Item 3990099045/13116
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 917394      在线人数 : 1431
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/13116


    题名: Betel nut arecoline induces different phases of growth arrest between normal and cancerous prostate cells through the reactive oxygen species pathway
    作者: Shih, LJ;Wang, JY;Jheng, JY;Siao, AC;Lin, YY;Tsuei, YW;Kuo, YC;Chuu, CP;Kao, YH
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Prostate cancer (PCa) is a reproductive system cancer in elderly men. We investigated the effects of betel nut arecoline on the growth of normal and cancerous prostate cells. Normal RWPE‐ 1 prostate epithelial cells, androgen‐independent PC‐3 PCa cells, and androgen‐dependent LNCaP PCa cells were used. Arecoline inhibited their growth in dose‐ and time‐dependent manners. Arecoline caused RWPE‐1 and PC‐3 cell cycle arrest in the G2/M phase and LNCaP cell arrest in the G0/G1 phase. In RWPE‐1 cells, arecoline increased the expression of cyclin‐dependent kinase (CDK)‐1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression. In PC‐3 cells, arecoline decreased CDK1, CDK2, CDK4, p21, p27, and cyclin D1 and D3 protein expression and increased cyclin B1 protein expression. In LNCaP cells, arecoline decreased CDK2, CDK4, and cyclin D1 expression; increased p21, p27, and cyclin D3 expression; had no effects on CDK1 and cyclin B1 expression. The antioxidant N‐acetylcysteine blocked the arecoline‐induced increase in reactive oxygen species production, decreased cell viability, altered the cell cycle, and changed the cell cycle regulatory protein levels. Thus, arecoline oxidant exerts differential effects on the cell cycle through modulations of regulatory proteins.
    日期: 2020-12-03
    關聯: International Journal of Molecular Sciences. 2020 Dec 3;21(23):Article number 9219.
    Link to: http://dx.doi.org/10.3390/ijms21239219
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000597496300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097093968
    显示于类别:[褚志斌] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP85097093968.pdf3209KbAdobe PDF351检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈