國家衛生研究院 NHRI:Item 3990099045/13117
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    题名: Adipokine-modulated immunological homeostasis shapes the pathophysiology of inflammatory bowel disease
    作者: Tsai, YW;Fu, SH;Dong, JL;Chien, MW;Liu, YW;Hsu, CY;Sytwu, HK
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Inflammatory colon diseases, which are a global health concern, include a variety of gastrointestinal tract disorders, such as inflammatory bowel disease and colon cancer. The pathogenesis of these colon disorders involves immune alterations with the pronounced infiltration of innate and adaptive immune cells into the intestines and the augmented expression of mucosal pro-inflammatory cytokines stimulated by commensal microbiota. Epidemiological studies during the past half century have shown that the proportion of obese people in a population is associated with the incidence and pathogenesis of gastrointestinal tract disorders. The advancement of understanding of the immunological basis of colon disease has shown that adipocyte-derived biologically active substances (adipokines) modulate the role of innate and adaptive immune cells in the progress of intestinal inflammation. The biomedical significance in immunological homeostasis of adipokines, including adiponectin, leptin, apelin and resistin, is clear. In this review, we highlight the existing literature on the effect and contribution of adipokines to the regulation of immunological homeostasis in inflammatory colon diseases and discuss their crucial roles in disease etiology and pathogenesis, as well as the implications of these results for new therapies in these disorders.
    日期: 2020-12-15
    關聯: International Journal of Molecular Sciences. 2020 Dec 15;21(24):Article number 9564.
    Link to: http://dx.doi.org/10.3390/ijms21249564
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000602842200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85098126309
    显示于类别:[司徒惠康] 期刊論文

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