國家衛生研究院 NHRI:Item 3990099045/13127
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    题名: On selecting the critical boundary functions in group-sequential trials with two time-to-event outcomes
    作者: Hamasaki, T;Hung, HMJ;Hsiao, CF;Evans, SR
    贡献者: Institute of Population Health Sciences
    摘要: We investigate selection of critical boundary functions for testing the hypotheses of two time-to-event outcomes as both primary endpoints or a primary and a secondary endpoint in group-sequential clinical trials, where (1) the effect sizes of endpoints are unequal, or (2) one endpoint is for short-term evaluation and the other for long-term evaluation. Bonferroni-Holm and fixed-sequence procedures are considered. We assess the effects of the magnitudes of the hazard ratios and the correlation between the endpoints on statistical powers and provide guidance for consideration.
    日期: 2021-02
    關聯: Contemporary Clinical Trials. 20201 Feb;101:Article number 106244.
    Link to: http://dx.doi.org/10.1016/j.cct.2020.106244
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1551-7144&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000709042300005
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85098731347
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