國家衛生研究院 NHRI:Item 3990099045/13133

NHRI > National Institute of Environmental Health Sciences > Lukas Jyuhn-Hsiarn Lee > Periodical Articles > Item 3990099045/13133

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13133

Title:	Voluntary exercise ameliorates synaptic pruning deficits in sleep-deprived adolescent mice
Authors:	Tuan, LH;Tsao, CY;Jyuhn-Hsiarn Lee, L;Lee, LJ
Contributors:	National Institute of Environmental Health Sciences
Abstract:	Adolescence is a critical period for brain development and adequate sleep during this period is essential for physical function and mental health. Emerging evidence has detailed the neurological impacts of sleep insufficiency on adolescents, as was unveiled by our previous study, microglia, one of the crucial contributors to synaptic pruning, is functionally disrupted by lack of sleep. Here, we provided evidence featuring the protective effect and the underlying mechanisms of voluntary exercise (VE) on microglial functions in an adolescent 72 h sleep deprivation (SD) model. We identified that the aberrant hippocampal neuronal activity and impaired short-term memory performance in sleep-deprived mice were prevented by 11 days of VE. VE significantly normalized the SD-induced dendritic spine increment and maintained the microglial phagocytic ability in sleep-deprived mice. Moreover, we found that the amendment of the noradrenergic signal in the central nervous system may explain the preventative effects of VE on the abnormalities of microglial and neuronal functions caused by SD. These data suggested that VE may confer protection to the microglia-mediated synaptic pruning in the sleep-deprived adolescent brains. Therefore, physical exercise could be a beneficial health practice for the adolescents that copes the adverse influence of inevitable sleep insufficiency.
Date:	2021-03
Relation:	Brain, Behavior, and Immunity. 2021 Mar;93:96-110.
Link to:	http://dx.doi.org/10.1016/j.bbi.2020.12.017
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0889-1591&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000632033900014
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85098656039
Appears in Collections:	[Lukas Jyuhn-Hsiarn Lee] Periodical Articles

Files in This Item:

File	Description	Size	Format
PUB33358980.pdf		9964Kb	Adobe PDF	273	View/Open

Loading...