國家衛生研究院 NHRI:Item 3990099045/13139
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    國家衛生研究院 NHRI > 癌症研究所 > 其他 > 期刊論文 >  Item 3990099045/13139


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    题名: PD-L1/PD-1 blockade in breast cancer: The immunotherapy era (Review)
    作者: Li, CJ;Lin, LT;Hou, MF;Chu, PY
    贡献者: National Institute of Cancer Research
    摘要: Breast cancer is a common malignant tumor in women. Triple‑negative breast cancer (TNBC) is highly invasive with a high rate of metastasis and poor prognosis. Programmed death ligand 1 (PD‑L1) plays an important role in mediating the escape of tumor cells from immune surveillance. There have been significant advances in understanding the biology of TNBC. This review presents a detailed discourse on the available data on the expression of PD‑L1 in breast cancer and preliminary clinical outcome of PD‑L1/PD‑1 inhibi‑ tors in breast cancer patients. Early clinical trials involving PD‑L1/PD‑1 inhibitors have exhibited efficacy in tumor response and/or disease control in patients with refractory metastatic breast cancer, particularly TNBC. Furthermore, the mechanisms and factors that influence the immunoediting process are summarized and their functions in detail are analyzed. Contents 1. Introduction 2. Overview of tumor immunotherapy 3. Biological characteristics of PD‑1/PD‑L1 4. Prognostic significance of PD‑1/PD‑L1 5. Significance of targeting PD‑1/PD‑L1 monoclonal antibody 6. Anti‑PD‑L1 therapy for breast cancer 7. Future perspectives.
    日期: 2020-11-03
    關聯: Oncology Reports. 2020 Nov 3;45(1):5-12.
    Link to: http://dx.doi.org/10.3892/or.2020.7831
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-335X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000598757000001
    Cited Times(Scopus): http://www.scopus.com/record/display.url?eid=2-s2.0-85097131387&origin=inward
    显示于类别:[其他] 期刊論文

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