國家衛生研究院 NHRI:Item 3990099045/13187
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13187


    Title: Late-onset epilepsy and subsequent increased risk of dementia
    Authors: Tsai, ZR;Zhang, HW;Tseng, CH;Peng, HC;Kok, VC;Li, GP;Hsiung, CA;Hsu, CY
    Contributors: Institute of Population Health Sciences
    Abstract: Inflammation is considered as a key pathogenesis factor of dementia and epilepsy. However, epilepsy's association with dementia, particularly its role in the development of dementia, remains unclear. To evaluate the association between epilepsy and the risk of dementia, in Taiwan, we have now conducted a retrospective cohort study comprising 675 individuals (age, ≥50 years) with epilepsy and 2,025 matched control subjects without epilepsy. In order to match individuals diagnosed with epilepsy with those with no diagnosis of epilepsy (comparison cohort), we utilized exact matching at a ratio of 1:3. Compared with those in the comparison cohort, individuals in the epilepsy cohort had a significantly increased risk of developing dementia (adjusted hazard ratio = 2.87, p < 0.001). A similar result has been observed after stratifying for sex (adjusted hazard ratio in males = 2.95, p < 0.001; adjusted hazard ratio in females = 2.66, p < 0.001). To conclude, based on these data, epileptic individuals ≥50 years were at a greater risk of developing dementia than people who do not have epilepsy, which indicates that a diagnosis of epilepsy presents a greater risk for the development of dementia.
    Date: 2021-02-15
    Relation: Aging. 2021 Feb 15;13(3):3573-3587.
    Link to: http://dx.doi.org/10.18632/aging.202299
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1945-4589&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000618834100002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85101289682
    Appears in Collections:[Chao A. Hsiung] Periodical Articles

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