國家衛生研究院 NHRI:Item 3990099045/13190
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13190


    Title: Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity
    Authors: Chen, PC;Shao, YT;Hsieh, MH;Kao, HF;Kuo, WS;Wang, SM;Chen, SH;Wu, LSH;Tsai, HJ;Wang, JY
    Contributors: Institute of Population Health Sciences
    Abstract: Virus-induced asthma is prevalent among children, but its underlying mechanisms are unclear. Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma. Nonetheless, the relationship between systemic virus infections, such as enterovirus infection, and the ensuing effects on allergic asthma development is unknown. Early-life enterovirus infection was correlated with higher risks of allergic diseases in children. Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period. Bone marrow-derived macrophages (BMDMs) from recovered EV-A71-infected mice showed sustained innate immune memory (trained immunity) that could drive naive T helper cells toward Th2 and Th17 cell differentiation when in contact with mites. Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naive recipient mice, which was inhibited by 2-deoxy-D-glucose (2-DG) pretreatment, suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.
    Date: 2021-01-13
    Relation: Cellular and Molecular Immunology. 2021 Jan 13;18:472-483.
    Link to: http://dx.doi.org/10.1038/s41423-020-00621-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1672-7681&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000608159300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85100204757
    Appears in Collections:[Hui-Ju Tsai] Periodical Articles

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