國家衛生研究院 NHRI:Item 3990099045/13200
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    题名: Multiplexed analysis of circulating IgA antibodies for SARS-CoV-2 and common respiratory pathogens in COVID-19 patients
    作者: Fang, ZF;Sun, BQ;Zhu, AR;Lin, LC;Zhao, JC;He, S;Huang, SK;Zhong, NS;Liu, ZG
    贡献者: National Institute of Environmental Health Sciences
    摘要: Previous studies have revealed a diagnostic role of pathogen-specific IgA in respiratory infections. However, co-detection of serum specific IgA for SARS-CoV-2 and common respiratory pathogens remains largely unexplored. This study utilizes a protein microarray technology for simultaneous and quantitative measurements of specific IgAs for 8 different respiratory pathogens including adenovirus, respiratory syncytial virus, influenza virus type A, influenza virus type B, parainfluenza virus, mycoplasma pneumoniae, chlamydia pneumoniae and SARS-CoV-2 in serum sample of COVID-19 patients. A total of 42 COVID-19 patients were included and categorized into severe cases (20 cases) and non-severe cases (22 cases). The results showed that co-detection rate of specific-IgA for SARS-CoV-2 with at least one pathogen were significantly higher in severe cases than that of non-severe cases (72.2% vs. 46.2%, p=0.014). Our study indicates that co-detection of IgA antibodies for respiratory pathogens might provide diagnostic value for the clinics and also be informative for risk stratification and disease management in COVID-19 patients.
    日期: 2021-05
    關聯: Journal of Medical Virology. 2021 May;93(5):3257-3260.
    Link to: http://dx.doi.org/10.1002/jmv.26829
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0146-6615&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000620719800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85101282722
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