國家衛生研究院 NHRI:Item 3990099045/13250
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    題名: A hospital-based surveillance system for studying genetic and antigenic evolution of enterovirus A71 in south Vietnam
    作者: Chung, WY;Khanh, TH;Luo, ST;Chang, WC;Quy, DT;Dan, TNH;Nhan, L;Thinh, LQ;Nga, N;Kuo, FL;Lien, LB;Su, IJ;Hung, NT;Lee, MS
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: Background: Introduction: Large-scale epidemics of enterovirus A71 (EV-A71) genotype occurred with different genotypes in 2005 (genotype C5) and 2011 (genotype C4a) in southern Vietnam. B5 had replaced C4 as the predominant genotype since 2013; however, some evidence suggested the reemergence of C4 since 2018. This study aims to investigate genetic and antigenic evolution of EV-A71 in south Vietnam.Methods and materials: Methods: National Health Research Institutes (NHRI), Taiwan has collaborated with Children's Hospital 1 (CH1), Ho Chi Minh City (HCMC), Vietnam to establish a hospital-based surveillance system of EV-A71 infections since 2012. Residual sera and throat swabs were collected from hand-foot-mouth disease (HFMD) inpatients for virological tests including virus isolation tested in CH1 using RD cells, and semi-nested RT-PCR (CODEHOP) and serum neutralization test performed in NHRI.Results: Based on virus isolation, EV71 positive rates were 6.8%, 16.0%, 2.7%, 9.6%, 5.2%, 1.6%, and 3.5% from 2012 to 2018, respectively, which are significantly lower than the positive rates tested using CODEHOP in the corresponding years (14.7%, 20.1%, 6.7%, 11.0%, 22.8%, 19.6%, and 6.0%). The results of genetic analysis indicated EV-A71 was the predominant serotypes in 2013, 2016 and 2017 and EV-A71 genotypes shifted from C4 in 2012 to B5 in 2013–2017. We found C4a and B5 had comparable number of virus isolates in 2018. Based on phylogenetic analysis, the genotype C4a viruses were likely imported from China and the genotype B5 viruses could be from southern Asia. Interestingly, the genotype B5 and C4a viruses circulating in HCMC have similar antigenicity based on neutralization tests using sera collected from children infected with EV-A71.Conclusion: In conclusion, international spreading of EV-A71 is common in southern Vietnam and EV-A71 epidemics cyclically occurred in 2–3 years since 2011. Enterovirus surveillance and vaccine development is urgently needed in Vietnam.
    日期: 2020-12
    關聯: International Journal of Infectious Diseases. 2020 Dec;101(Suppl. 1):354.
    Link to: http://dx.doi.org/10.1016/j.ijid.2020.09.928
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1201-9712&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000612135101128
    顯示於類別:[李敏西] 會議論文/會議摘要
    [蘇益仁(2002-2015)] 會議論文/會議摘要

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