國家衛生研究院 NHRI:Item 3990099045/13294
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    题名: Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles
    作者: Wu, WT;Jung, WT;Lee, HL
    贡献者: National Institute of Environmental Health Sciences
    摘要: The purpose of this study was to assess the effects of lipid peroxidation with occupational exposure to different types of nanomaterials (NMs). In this cross-sectional study, urine and exhaled breath condensate (EBC) samples were collected from 80 NM-handling workers [30 workers handling nano-titanium oxide (nano-TiO2), 28 handling nano-silicon dioxide (nano-SiO2), 22 handling carbon nanotubes (CNTs)], and 69 controls (office workers) from 2010 to 2012. Urinary 8-isoPGF(2 alpha), 2,3 dinor-8-isoPGF(2 alpha), PGF(2 alpha), and EBC 8-iso PGF(2 alpha) were measured as lipid peroxidation biomarkers in 2013. A significant positive correlation was found between 8-isoPGF(2 alpha), 2,3 dinor-8-isoPGF(2 alpha), PGF(2 alpha), and total isoprostane in urine. Furthermore, significant positive correlations were noted between EBC 8-iso PGF(2 alpha) and urinary 2,3 dinor-8-isoPGF(2 alpha) (Spearman correlation r = 0.173, p = 0.035). Exposure to nano-TiO2 resulted in significantly higher levels of urinary 8-isoPGF(2 alpha), 2,3 dinor-8-isoPGF(2 alpha) and PGF(2 alpha), even after controlling for confounding factors. Moreover, significant associations and exposure intensity-response relationships between EBC 8-iso PGF(2 alpha) and NMs were observed in workers, whether handling nano-TiO2, nano-SiO2, or CNTs. Among them, the significant trends were identified based on the intensity of risk levels. These results provided evidence that exposure to nano-TiO2, nano-SiO2, and CNTs may lead to lipid peroxidation in EBC. For routine biomonitoring purposes, this finding, which came through noninvasive methods, may be useful for workers exposed to NMs.
    日期: 2021-06
    關聯: Nanotoxicology. 2021 Jun;15(5):577-587.
    Link to: http://dx.doi.org/10.1080/17435390.2021.1879303
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1743-5390&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000617226700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85101450234
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