國家衛生研究院 NHRI:Item 3990099045/13299
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    题名: Protocol for human placental mesenchymal stem cell therapy in a murine model of intra-abdominal infection of hypervirulent Klebsiella
    作者: Wang, LT;Chiu, SK;Lee, W;Siu, LK;Liu, KJ;Yen, ML;Yen, BL
    贡献者: Institute of Cellular and Systems Medicine;National Institute of Infectious Diseases and Vaccinology;National Institute of Cancer Research
    摘要: Hypervirulent Klebsiella pneumoniae (hvKP) strains cause extra-pulmonary infections such as intra-abdominal infection (IAI) even in healthy individuals due to its resistance to polymorphonuclear neutrophil (PMN) killing and a high incidence of multidrug resistance. To assess whether human placental mesenchymal stem cell (PMSC) therapy can be an effective treatment option, we established a murine model of hvKP-IAI to evaluate immune cell modulation and bacterial clearance for this highly lethal infection. This protocol can rapidly assess potential therapies for severe bacterial IAIs.
    日期: 2021-03-19
    關聯: STAR Protocols. 2021 Mar 19;2:Article number 100337.
    Link to: http://dx.doi.org/10.1016/j.xpro.2021.100337
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85122800904
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