國家衛生研究院 NHRI:Item 3990099045/13310
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    题名: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal
    作者: Hieda, M;Matsumoto, T;Isobe, M;Kurono, S;Yuka, K;Kametaka, S;Wang, JY;Chi, YH;Kameda, K;Kimura, H;Matsuura, N;Matsuura, S
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive. The inner nuclear membrane SUN proteins, SUN1 and SUN2, have diverse functions together with the outer nuclear membrane nesprin proteins, which comprise the LINC complex. We found that depletion of SUN1 leads to Golgi complex dispersion with maintenance of ministacks and retained function for vesicle transport through the Golgi complex. In addition, SUN2 associates with microtubule plus-end-directed motor KIF20A, possibly via nesprin-2. KIF20A plays a role in the Golgi dispersion in conjunction with the SUN2-nesprin-2 LINC complex in SUN1-depleted cells, suggesting that SUN1 suppresses the function of the SUN2-nesprin-2 LINC complex under a steady-state condition. Further, SUN1-knockout mice, which show impaired cerebellar development and cerebellar ataxia, presented altered Golgi morphology in Purkinje cells. These findings revealed a regulation of the Golgi organization by the LINC complex.
    日期: 2021-03-08
    關聯: Scientific Reports. 2021 Mar 8;11:Article number 5358.
    Link to: http://dx.doi.org/10.1038/s41598-021-84750-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000627449200005
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102148739
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