國家衛生研究院 NHRI:Item 3990099045/13338
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    题名: Anti-inflammatory effects induced by near-infrared light irradiation through M2 macrophage polarization
    作者: Liao, WT;Hung, CH;Liang, SS;Yu, S;Lu, JH;Lee, CH;Chai, CY;Yu, HS
    贡献者: National Institute of Environmental Health Sciences
    摘要: Near-infrared (NIR) can penetrate into the dermis. NIR is able to regulate cutaneous component cells and immune cells, and shows significant anti-inflammatory therapeutic effects. However, the mechanisms of these effects are largely unknown. The purpose of this study is to elucidate NIR-induced molecular mechanisms on macrophages, since macrophages play initial roles in directing immune responses by their M1/M2 polarizations. Proteomic analysis revealed that NIR radiation enhanced the expression of mitochondrial respiratory gene citrate synthase (CS). This increased CS expression was triggered by NIR-induced histone-3-lysine-4 hypermethylation on the CS gene promoter, but not by heat, which led to macrophage M2 polarization and finally resulted in TGF-β1 release from CD4+ cells. These cellular effects were validated in human primary macrophages and abdominal NIR-irradiated mouse experiments. In a PMA-induced inflammatory model on mouse ear, we confirmed that NIR irradiation induced significant anti-inflammatory effects via decreased M1 counts, reduced TNF-α, and increased CCL22/TGF-β1 levels.
    日期: 2021-08
    關聯: Journal of Investigative Dermatology. 2021 Aug;141(8):2056-2066.e10.
    Link to: http://dx.doi.org/10.1016/j.jid.2020.11.035
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-202X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000697502000005
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85104108273
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