國家衛生研究院 NHRI:Item 3990099045/13359
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    题名: Neurofilament light chain as novel blood biomarker of disturbed neuroaxonal integrity in patients with ketamine dependence
    作者: Liu, YL;Bavato, F;Chung, AN;Liu, TH;Chen, YL;Huang, MC;Quednow, BB
    贡献者: Center for Neuropsychiatric Research
    摘要: OBJECTIVES: Chronic and heavy ketamine use has been associated with persistent neurocognitive impairment and structural brain abnormalities. Blood levels of neurofilament light chain (NFL) was recently proposed as a measure of axonal integrity in several neuropsychiatric disorders. We aimed to characterize the axonal neurotoxicity of chronic ketamine use and its relationship to relevant clinical outcomes. METHODS: We enrolled 65 treatment-seeking ketamine-dependent patients (55 males and 10 females) and 60 healthy controls (51 males and 9 females). Blood NFL levels measured by single molecule array (SiMoA) immunoassay. We compared NFL levels between groups and used regression analyses to identify clinical variables related to NFL levels. RESULTS: Ketamine-dependent patients had significantly higher NFL levels compared to controls (p<.001). A multivariate regression showed that age (p<.05) and lifetime history of major depressive disorder (MDD) (p<.01) predicted high NFL blood levels in patients. Subsequent group comparisons showed that specifically ketamine-dependent patients with a lifetime history of MDD had significantly increased NFL levels than those without (p<.05). CONCLUSIONS: These results suggest substantial neuroaxonal alterations following chronic and heavy ketamine use. The pronounced increase of NFL levels in the MDD subgroup warrants further investigation of a potential neuroaxonal vulnerability of depressed patients to ketamine.
    日期: 2021-11
    關聯: World Journal of Biological Psychiatry. 2021 Nov;22(9):713-721.
    Link to: http://dx.doi.org/10.1080/15622975.2021.1907709
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1562-2975&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000715243000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85105187033
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