國家衛生研究院 NHRI:Item 3990099045/13418

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13418

Title:	Nitrogen-doped titanium dioxide mixed with calcium peroxide and methylcellulose for dental bleaching under visible light activation
Authors:	Thacker, M;Chen, YN;Lin, CP;Lin, FH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	The available tooth whitening products in the market contain high concentrations of hydrogen peroxide (H2O2 ) as an active ingredient. Therefore, in order to curb the high H2O2 concentration and instability of liquid H2O2, this study evaluated the efficacy and cytotoxicity of the bleaching gel composed of 10% calcium peroxide (CaO2 ) and visible-light-activating nitrogen-doped titanium dioxide (N-TiO2 ) with methyl cellulose as a thickener. Extracted bovine teeth were discolored using coffee and black tea stain solution and were divided into two groups (n = 6). Bleaching was performed thrice on each tooth specimen in both the groups, with one minute of visible light irradiation during each bleaching time. The CIELAB Lab* values were measured pre-and post-bleaching. The N-TiO2 calcinated at 350◦C demonstrated a shift towards the visible light region by narrowing the band gap energy from 3.23 eV to 2.85 eV. The brightness (∆L) and color difference (∆E) increased as bleaching progressed each time in both the groups. ANOVA results showed that the number of bleaching significantly affected ∆E (p < 0.05). The formulated bleaching gel exhibits good biocompatibility and non-toxicity upon exposure to 3T3 cells. Our findings showed that CaO2-based bleaching gel at neutral pH could be a stable, safe, and effective substitute for tooth whitening products currently available in the market.
Date:	2021-04-04
Relation:	International Journal of Molecular Sciences. 2021 Apr 4;22(7):Article number 3759.
Link to:	http://dx.doi.org/10.3390/ijms22073759
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000638626500001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85103516683
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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