國家衛生研究院 NHRI:Item 3990099045/13484
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13484


    Title: Optical volumetric brain imaging: Speed, depth, and resolution enhancement
    Authors: Huang, SH;Irawati, N;Chien, YF;Lin, JY;Tsai, YH;Wang, PY;Chu, LA;Li, ML;Chiang, AS;Tsia, KK;Chu, SW
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Understanding how the brain functions is one of the grand challenges in modern scientific research. Similar to a computer, a functional brain is composed of hardware and software. The major bottleneck lies in the difficulty to directly observe the brain 'software', i.e. the rule and operating information used by the brain that might emerge from pan-neuron/synapse connectome. A recognized strategy for probing the functional connectome is to perform volumetric imaging in brains with high spatiotemporal resolution and deep brain penetration. Among various imaging technologies, optical imaging offers appealing combinations including spatial resolution of sub-micrometer to nanometer, temporal resolution of second to millisecond, penetration depth of millimeter or deeper, and molecular contrast based on the abundant choices of fluorescent indicators. Thus, it is ideal for enabling three-dimensional functional brain mapping of small animal models. In this review, we focus on recent technological advances in optical volumetric imaging, with an emphasis on the tools and methods for enhancing imaging speed, depth, and resolution. The review could serve as a quantitative reference for physicists and biologists to choose the techniques better suited for specific applications, as well as to stimulate novel technical developments to advance brain research.
    Date: 2021-06-01
    Relation: Journal of Physics D-Applied Physics. 2021 Jun 1;54(32):Article number 323002.
    Link to: http://dx.doi.org/10.1088/1361-6463/abff7b
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3727&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000657114700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85107979722
    Appears in Collections:[Others] Periodical Articles

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