國家衛生研究院 NHRI:Item 3990099045/13503
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    题名: Ergosta-7, 9 (11), 22-trien-3Beta-ol interferes with lps docking to lbp, cd14, and tlr4/md-2 co-receptors to attenuate the nf-kappab inflammatory pathway in vitro and drosophila
    其它题名: Ergosta-7, 9 (11), 22-trien-3β-ol interferes with lps docking to lbp, cd14, and tlr4/md-2 co-receptors to attenuate the nf-κb inflammatory pathway in vitro and drosophila
    作者: Hsieh, WT;Hsu, MH;Lin, WJ;Xiao, YC;Lyu, PC;Liu, YC;Lin, WY;Kuo, YH;Chung, JG
    贡献者: Institute of Population Health Sciences
    摘要: Ergosta-7, 9 (11), 22-trien-3β-ol (EK100) was isolated from Cordyceps militaris, which has been used as a traditional anti-inflammatory medicine. EK100 has been reported to attenuate inflammatory diseases, but its anti-inflammatory mechanism is still unclear. We were the first to investigate the effect of EK100 on the Toll-like receptor 4 (TLR4)/nuclear factor of the κ light chain enhancer of B cells (NF-κB) signaling in the lipopolysaccharide (LPS)-stimulated RAW264.7 cells and the green fluorescent protein (GFP)-labeled NF-κB reporter gene of Drosophila. EK100 suppressed the release of the cytokine and attenuated the mRNA and protein expression of pro-inflammatory mediators. EK100 inhibited the inhibitor kappa B (IκB)/NF-κB signaling pathway. EK100 also inhibited phosphatidylinositol-3-kinase (PI3K)/Protein kinase B (Akt) signal transduction. Moreover, EK100 interfered with LPS docking to the LPS-binding protein (LBP), transferred to the cluster of differentiation 14 (CD14), and bonded to TLR4/myeloid differentiation-2 (MD-2) co-receptors. Compared with the TLR4 antagonist, resatorvid (CLI-095), and dexamethasone (Dexa), EK100 suppressed the TLR4/AKT signaling pathway. In addition, we also confirmed that EK100 attenuated the GFP-labeled NF-κB reporter gene expression in Drosophila. In summary, EK100 might alter LPS docking to LBP, CD14, and TLR4/MD-2 co-receptors, and then it suppresses the TLR4/NF-κB inflammatory pathway in LPS-stimulated RAW264.7 cells and Drosophila.
    日期: 2021-06-17
    關聯: International Journal of Molecular Sciences. 2021 Jun 17;22(12):Article number 6511.
    Link to: http://dx.doi.org/10.3390/ijms22126511
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000666203600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85108079965
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