國家衛生研究院 NHRI:Item 3990099045/13570
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    题名: Increased Nectin-4 levels in chronic ketamine abusers and the relationship with lower urinary tract symptoms
    作者: Chang, HM;Chen, PY;Fang, CP;Liu, TH;Wu, CT;Hsu, YC;Kuo, HW;Liu, YL;Huang, MC
    贡献者: Center for Neuropsychiatric Research
    摘要: Persistent ketamine use causes susceptibility to addiction and bladder toxicity. We examined the association of lower urinary tract symptoms and levels of Nectin-4, a member of the cell adhesion molecules that is essential for maintaining the urothelium barrier in chronic ketamine abusers. We measured the plasma levels of Nectin-4 in 88 patients with ketamine dependence and 69 controls. Patients with ketamine dependence were assessed for ketamine use variables, psychological symptoms, and lower urinary tract symptoms. We found Nectin-4 levels were increased in ketamine-dependent patients compared to the controls (p < 0.0001). Patients with urinary tract symptoms exhibited lower Nectin-4 levels than those without (p = 0.021). Our results suggest an up-regulation of Nectin-4 following chronic and heavy ketamine use. Patients with ketamine dependence with a compromised upregulation of Nectin-4 are likely to have more severe urinary tract symptoms. The mechanisms underlying the involvement of Nectin-4 in ketamine addiction and bladder toxicity warrant future investigation.
    日期: 2021-07-22
    關聯: Environmental Toxicology and Pharmacology. 2021 Jul 22;87:Article number 103714.
    Link to: http://dx.doi.org/10.1016/j.etap.2021.103714
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1382-6689&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000696705400009
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85111003314
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