國家衛生研究院 NHRI:Item 3990099045/13613
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 912819      線上人數 : 1189
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/13613


    題名: Lattice Boltzmann method to simulate three-dimensional ion channel flow using fourth order Poisson-Nernst-Planck-Bikerman model
    作者: Saurabh, K;Solovchuk, MA;Sheu, TWH
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Over the past three decades, the lattice Boltzmann method (LBM) has been applied to a vast range of hydrodynamic and non-hydrodynamic (e.g., ion transport) systems. In conjunction with the immersed boundary method (IBM), the LBM has been successfully implemented to solve systems with complex geometries. In this study, the immersed boundary-lattice Boltzmann method (IB-LBM) is implemented to simulate nanoscale ion transport. Traditionally, ion transport is described through the Poisson-Nernst-Planck (PNP) equations where ionic interactions are included. In the current paper, the fourth order Poisson-Nernst-Planck-Bikerman (4PNPBik) model has been used. In addition to ionic interactions, the 4PNPBik model includes the effects of the finite size of particles (ions and water) and interactions between ions and its surrounding medium. Applicability of the 4PNPBik model is demonstrated through comparison of the experimental and predicted ion activity. Implementation of the 4PNPBik model has been validated by comparing the predicted current-voltage curve with the analytical result. The transient receptor potential (TRP) ion channel of the vanilloid group (TRPV4) is used to demonstrate the applicability of this approach. The TRPV4 is a nonselective cation channel that prefers divalent cationic species over monovalent cations. In this study, this selectivity is demonstrated by comparing the concentration profiles of calcium, sodium, and chloride ions. Further, the role of the finite size of particles and nonlocal electrostatics is discussed by comparing the results obtained from the PNP and 4PNPBik models under identical initial and boundary conditions.
    日期: 2021-08-19
    關聯: Physics of Fluids. 2021 Aug 19;33(8):Article number 081910.
    Link to: http://dx.doi.org/10.1063/5.0062512
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1070-6631&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000686299700009
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85113378409
    顯示於類別:[馬克沁] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000686299700009.pdf1304KbAdobe PDF111檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋