國家衛生研究院 NHRI:Item 3990099045/13630
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13630


    Title: Low levels of microRNA-10a in cardiovascular endothelium and blood serum are related to human atherosclerotic disease
    Authors: Kuo, JT;Tsai, HE;Lin, CT;Lee, CI;Lee, PL;Ruan, YR;Chiu, JJ;Lee, DY
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Background. MicroRNA-10a (miR-10a) inhibits transcriptional factor GATA6 to repress inflammatory GATA6/VCAM-1 signaling, which is regulated by blood flow to affect endothelial function/dysfunction. This study aimed to identify the expression patterns of miR-10a/GATA6/VCAM-1 in vivo and study their implications in the pathophysiology of human coronary artery disease (CAD), i.e., atherosclerosis. Methods. Human atherosclerotic coronary arteries and nondiseased arteries were used to detect the expressions of miR-10a/GATA6/VCAM-1 in pathogenic vs. normal conditions. In addition, sera from CAD patients and healthy subjects were collected to detect the level of circulating miR-10a. Results. The comparison of human atherosclerotic coronary arteries with nondiseased arteries demonstrated that lower levels of endothelial miR-10a are related to human atherogenesis. Moreover, GATA6/VCAM-1 (a downstream target of miR-10a) was highly expressed in the endothelium, accompanied by the reduced levels of miR-10a during the development of human atherosclerosis. In addition, CAD patients had a significantly lower concentration of miR-10a in their serum compared to healthy subjects. Conclusions. Our findings suggest that low miR-10a and high GATA6/VCAM-1 in the cardiovascular endothelium correlates to the development of human atherosclerotic lesions, suggesting that miR-10a signaling has the potential to be developed as a biomarker for human atherosclerosis.
    Date: 2021-07
    Relation: Cardiology Research and Practice. 2021 Jul;2021:Article number 1452917.
    Link to: http://dx.doi.org/10.1155/2021/1452917
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2090-8016&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000678918000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85111561084
    Appears in Collections:[Jeng-Jiann Chiu ] Periodical Articles

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