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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13668


    Title: Saccharpiscinols A–C: Flavans with potential inflammatory activities from one actinobacteria Saccharomonospora piscinae
    Authors: Su, YS;Chen, JJ;Cheng, MJ;Chai, CY;Kwan, AL;Huang, JC;Kuo, YH
    Contributors: NHRI Graduate Student Program
    Abstract: Phytochemical investigation and chromatographic separation of extracts from the actino-bacteria strain Saccharomonospora piscinae that was isolated from dried fishpond sediment of Kouhu township, in the south of Taiwan, led to the isolation of three new compounds, saccharpiscinols A– C (1–3, respectively), and three new natural products, namely (2S)-5,7,3′,4′-tetrahydroxy-6,8-dime-thylflavanone (4), methyl-4-hydroxy-2-methoxy-6-methylbenzoate (5), and (±)-7-acetyl-4,8-dihy-droxy-6-methyl-1-tetralone (6). Compounds 4–6 were reported before as synthesized products, herein, they are reported from nature for the first time. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic data analysis (1D-and 2D-NMR, MS, and UV) and comparison with literature data. The effect of some isolates on the inhibition of NO production in lipopolysaccharide-activated RAW 264.7 murine macrophages was evaluated. Saccharpiscinol A showed inhibitory activities against LPS-induced NO production.
    Date: 2021-08-13
    Relation: Molecules. 2021 Aug 13;26(16):Article number 4909.
    Link to: http://dx.doi.org/10.3390/molecules26164909
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000690179800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85112731874
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