國家衛生研究院 NHRI:Item 3990099045/13707
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13707


    Title: Norepinephrine administration is associated with higher mortality in dialysis requiring acute kidney injury patients with septic shock
    Authors: Chen, YY;Wu, VC;Huang, WC;Yeh, YC;Wu, MS;Huang, CC;Wu, KD;Fang, JT;Wu, CJ;Wu, VC;Lai, TS;Lin, YF;Tsai, IJ;Lai, CF;Huang, TM;Chu, TS;Chen, YM;Chang, YH;Yeh, YC;Lai, CH;Tseng, LJ;Wu, KD;Wang, JJ;Chen, CY;Shiao, CC;Wang, WJ;Lin, JH;Wu, CH;Wu, CJ;Lu, KC;Kan, WC;Huang, CC;Chou, CY;Yang, YF;Tsai, JP;Hu, FC;Lee, CT;Chen, JB;Lee, CH;Lee, WC;Li, LC;Chen, TC;Lin, HYH;Chen, YC;Lee, CC;Sun, CY;Pan, HC;Chang, MY;Jenq, CC;Lin, CY;Chang, CH;Tsai, TY;Chen, CM;Lin, ET;Wu, CJ;Lin, CJ;Wu, PC;Kuo, FC;Weng, CJ;Chen, LK;Lin, SL;Yang, WS;Hsu, WD;Leu, JG;Chang, JT;Liou, HH;Hsu, KH;Wu, MJ;Huang, CT;You, ZH;Chang, CF;Chen, TW;Chen, HH;Chang, FC;Lin, YC;Wu, MS;Kao, CC;Hung, SC;Kuo, KL;Wu, CH;Tarng, DC;Chen, JY;Yang, CY;Lee, KH;Ko, SW;The NSARF and CAKS Group
    Contributors: Institute of Population Health Sciences
    Abstract: (1) Background: Norepinephrine (NE) is the first-line vasoactive agent used in septic shock patients; however, the effect of norepinephrine on dialysis-required septic acute kidney injury (AKI-D) patients is uncertain. (2) Methods: To evaluate the impact of NE on 90-day mortality and renal recovery in septic AKI-D patients, we enrolled patients in intensive care units from 30 hospitals in Taiwan. (3) Results: 372 patients were enrolled and were divided into norepinephrine users and non-users. After adjustment by Inverse probability of treatment weighted (IPTW), there was no significant difference of baseline comorbidities between the two groups. NE users had significantly higher 90-day mortality rate and using NE is a strong predictor of 90-day mortality in the multivariate Cox regression (HR = 1.497, p = 0.027) after adjustment. The generalized additive model disclosed norepinephrine alone exerted a dose–dependent effect on 90-day mortality, while other vasoactive agents were not. (4) Conclusion: Using norepinephrine in septic AKI-D patients is associated with higher 90-day mortality and the effect is dose-dependent. Further study to explore the potential mechanism is needed.
    Date: 2018-09-12
    Relation: Journal of Clinical Medicine. 2018 Sep 12;7(9):Article number 274.
    Link to: http://dx.doi.org/10.3390/jcm7090274
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2077-0383&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085772111
    Appears in Collections:[Li-Kwang Chen] Periodical Articles

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