國家衛生研究院 NHRI:Item 3990099045/13725
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    题名: The evolving role of ferroptosis in breast cancer: Translational implications present and future
    作者: Lin, HY;Ho, HW;Chang, YH;Wei, CJ;Chu, PY
    贡献者: National Institute of Cancer Research
    摘要: Breast cancer (BC) is the most common malignancy among women worldwide. The dis-covery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC.
    日期: 2021-09-12
    關聯: Cancers. 2021 Sep 12;13(18):Article number 4576.
    Link to: http://dx.doi.org/10.3390/cancers13184576
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2072-6694&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000699313300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85114605878
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