國家衛生研究院 NHRI:Item 3990099045/13759
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    題名: 用於穩定油包水乳液及控制釋放生物活性物質之山梨醇酐聚酯複合體
    作者: 黃明熙;黃瓊儀;莊再成;冷治湘;劉士任;陳信偉
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: 本发明揭示一种在水包油包水(W/O/W)乳液中的组合物,其组成成分包括:(a)含H2O的连续水相;(b)分散在连续水相间的油相或油壳;以及(c)用于稳定连续水相和油相(或油壳)界面的亲水性聚合物,使其形成水包油(O/W)乳液。油相或油壳包括:(i)油、(ⅱ)分散在油或油壳内的内部水相,以及(ⅲ)一亲脂性山梨醇酐‑聚酯复合体,可稳定油和内部水相之间的界面,以形成油包水(W/O)乳液。该亲脂性山梨醇酐‑聚酯复合体包含:(1)山梨醇酐,以及(2)接合到山梨醇酐上的丙交酯‑己内酯共聚物或聚乳酸。A composition in a water-in-oil-in-water (W/O/W) emulsion is disclosed. The composition comprises: (a) a continuous aqueous phase, comprising H2O; (b) an oil phase or an oil shell, dispersed in the continuous aqueous phase; and (c) a hydrophilic polymer, stabilizing an interface between the continuous aqueous phase and the oil phase or the oil shell to form the water-in-oil-in-water (W/O/W) emulsion. The oil phase or the oil shell comprises: (i) oil; (ii) an internal aqueous phase, dispersed within the oil or the oil shell; and (iii) a lipophilic sorbitan-polyester conjugate, stabilizing an interface between the oil and the inner aqueous phase to form a water-in-oil (W/O) emulsion. The lipophilic sorbitan-polyester conjugate comprises: (1) sorbitan; and (2) poly(lactide-co-Epsilon-caprolactone) or polylactic acid (polylactide), conjugated to the sorbitan.
    日期: 2017-11
    關聯: 2017 2017-11-28(CN107405304A).
    Link to: https://worldwide.espacenet.com/patent/search?q=pn%3dCN107405304A
    顯示於類別:[黃明熙] 專利
    [莊再成] 專利
    [冷治湘] 專利
    [劉士任] 專利
    [陳信偉] 專利

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