國家衛生研究院 NHRI:Item 3990099045/13775
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    题名: Neurofilament light chain is a novel biomarker for major depression and related executive dysfunction
    作者: Chen, MH;Liu, YL;Kuo, HW;Tsai, SJ;Hsu, JW;Huang, KL;Tu, PC;Bai, YM
    贡献者: Center for Neuropsychiatric Research
    摘要: BACKGROUND: Evidence suggests that major depressive disorder is related to neuroaxonal injury and that neurofilament light chain (NfL) is a biomarker of neuroaxonal injury. In addition, proinflammatory cytokines have been reported to be associated with major depression and neuroaxonal injury. METHODS: Forty patients with major depression and 40 age- and sex-matched healthy control subjects were enrolled for the measurement of NfL and proinflammatory cytokines and assessment of executive function. General linear models were used to examine the association between NfL levels, proinflammatory cytokine levels, and executive function. RESULTS: Patients with major depressive disorder exhibited significantly higher NfL levels (p = 0.007) than the control subjects. NfL levels were positively related to log-transformed levels of tumor necrosis factor (TNF)-α (p = 0.004). Higher levels of NfL (p = 0.002) and TNF-α (p = 0.013) were associated with greater deficits in executive function. DISCUSSION: NfL was a novel biomarker for major depressive disorder and related executive dysfunction. Further studies are necessary to elucidate the role of NfL in the pathophysiology of major depression and related cognitive impairment.
    日期: 2022-02-11
    關聯: International Journal of Neuropsychopharmacology. 2022 Feb 11;25(2):99-105.
    Link to: http://dx.doi.org/10.1093/ijnp/pyab068
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1461-1457&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000754035600002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85124498504
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