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http://ir.nhri.org.tw/handle/3990099045/13782
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| Title: | Association between air pollution and lung lobar emphysema in COPD |
| Authors: | Tung, NT;Ho, SC;Lu, YH;Chen, TT;Lee, KY;Chen, KY;Wu, CD;Chung, KF;Kuo, HP;Thao, HNX;Dung, HB;Thuy, TPC;Wu, SM;Kou, HY;Lee, YL;Chuang, HC |
| Contributors: | National Institute of Environmental Health Sciences |
| Abstract: | The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear. This study examined the association of particulate matter <2.5 mu m in aerodynamic diameters (PM2.5) (<= 2.5 mu m), nitrogen dioxide (NO2), and ozone (O-3) level of exposure with the presence of emphysema in 86 patients with chronic obstructive pulmonary disease (COPD). Exposure to the air pollution estimated using the land-use regression model was associated with lung function, BODE (a body mass index, degree of obstruction, dyspnea severity, and exercise capacity index) quartiles, and emphysema measured as low-attenuation areas on high-resolution CT (HR-CT) lung scans. Using paraseptal emphysema as the reference group, we observed that a 1 ppb increase in O-3 was associated with a 1.798-fold increased crude odds ratio of panlobular emphysema (p < 0.05). We observed that PM2.5 was associated with BODE quartiles, modified Medical Research Council (mMRC) dyspnea score, and exercise capacity (all p < 0.05). We found that PM2.5, NO2, and O-3 were associated with an increased degree of upper lobe emphysema and lower lobe emphysema (all p < 0.05). Furthermore, we observed that an increase in PM2.5, NO2, and O-3 was associated with greater increases in upper lobe emphysema than in lower lobe emphysema. In conclusion, exposure to O-3 can be associated with a higher risk of panlobular emphysema than paraseptal emphysema in patients with COPD. Emphysema severity in lung lobes, especially the upper lobes, may be linked to air pollution exposure in COPD. |
| Date: | 2021-09 |
| Relation: | Frontiers in Medicine. 2021 Sep;8:Article number 705792. |
| Link to: | http://dx.doi.org/10.3389/fmed.2021.705792 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2296-858X&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000703289700001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116429414 |
| Appears in Collections: | [其他] 期刊論文
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| ISI000703289700001.pdf | | 241Kb | Adobe PDF | 182 | View/Open |
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